The NFPA 2001 Standard for Clean Agent Fire Extinguishing Systems gives guidelines for blends that contain HFC-134a or HCFC-22 and other acceptable total flooding agents, rather than referring to HFC-134a or HCFC-22 alone.

The NFPA 2001 Standard for Clean Agent Fire Extinguishing Systems gives guidelines for blends that contain HFC-134a or HCFC-22 and other acceptable total flooding agents, rather than referring to HFC-134a or HCFC-22 alone.

This agent contains CO ₂, which is intended to increase blood oxygenation and cerebral blood flow in low oxygen atmospheres. The design concentration should result in no more than 5% CO ₂.

For operations that install and maintain total flooding systems using this agent, EPA recommends the following:
- install and use adequate ventilation ;
- clean up all spills immediately in accordance with good industrial hygiene practices; and
- provide training for safe handling procedures to all employees that would be likely to handle containers of the agent or extinguishing units filled with the agent.

Use of the agent should be in accordance with the safety guidelines in the latest edition of the NFPA 2001 Standard for Clean Agent Fire Extinguishing Systems.

Extinguisher bottles should be clearly labeled with the potential hazards associated with the use of HFC-125 and d-limonene, as well as handling procedures to reduce risk resulting from these hazards.

Use of the agent should be in accordance with the safety guidelines in the latest edition of the NFPA 2001 Standard for Clean Agent Fire Extinguishing Systems.

Extinguisher bottles should be clearly labeled with the potential hazards associated with the use of HFC-227ea and d-limonene, as well as handling procedures to reduce risk resulting from these hazards.

For use in both normally occupied and unoccupied areas.